Post Zepbound anxiety?
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33 year old female. Really this is just going to be a ramble because, I don’t know. This is my experience, seeing if anyone has any perspective or something similar. I’ll start by saying I have had general anxiety in different variations all throughout my life. For years it’s been controlled, no medication. I began Zepbound August 2025 2.5 mg for 4 weeks lost about 2 pounds zero side effects. September, went to 5 mg, instantly became sick, almost quit several times . Eventually got it worked out. Stayed on 5mg up until Monday, November 24th, 2025, went to 7.5. Within 24 hours of that dose I began feeling very anxious. Went to the zoo with my daughter and could barely focus that night I went to bed, and was woken up around midnight with intense fear, and panic. I had several debilitating panic attacks over the next few days. Wasnt sleeping, irrational, ended up in the ER that Sunday. Dehydrated, exhausted, and still panicking. Was given some short term anxiety meds. The next day followed up with my PCP and prescriber of zepbound. Weight wise I was doing amazing. 5’6 started at 240, and was down to 200 pounds. But mentally after a week of torture I was mentally and emotionally done. We decided I was going to stop. I was prescribed buspirone 7.5 mg twice a day. I’ve been on this since the last week of November. While it helped some and I’ve thankfully haven’t had any panic attacks . I’m still very anxious most days. At this point the zepbound should be out of my system, but I’m still feeling the effects it triggered. I’ve deep dived, & done so many different searches. I’ve got an upcoming appointment/ sonogram with my OB to determine if I have PCOS. I feel as though my anxiety may be hormonal related. As it is most intense a few days before my menstrual cycle. The two could have nothing to do with each other. I know anxiety is a trial and error when it comes to mediation, and I am on a very low dose. I just know 6 months ago I felt “normal” and now I have to convince myself every morning that I’m not going to war, just waking up to spend the day, doing what I love, spending it with my toddler.
Details
- Subreddit
- r/Zepbound
- Author
- u/Consistent_Trifle238
- Posted
- Feb 12, 2026 at 4:55 PM UTC
AI Analysis
- Medication
- tirzepatide, buspirone
- Condition
- anxiety, panic attacks, possible PCOS, weight loss/obesity